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FK506

    
98%

FK506

源葉(MedMol)
S80090 一鍵復(fù)制產(chǎn)品信息
109581-93-3
C44H69NO12.H2O
822.03
他克莫司一水合物;FK-506一水合物; 他克莫司水合物; 大環(huán)哌喃一水合物; [3S-[3R[E(1S,3S,4S)],4S,5R,8S,9E,12R,14R,15S,16R,18S,19S,26aR]]-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-十六氫-5,19-二羥基-3-[2-(4-羥基-3-甲氧基環(huán)已基)-1-甲基乙烯基]-14,16-二
貨號 規(guī)格 價(jià)格 上海 北京 武漢 南京 購買數(shù)量
S80090-5mg 98% ￥136.00 7 - - -
S80090-10mg 98% ￥190.40 8 - - -
S80090-50mg 98% ￥340.00 2 - - -
S80090-250mg 98% ￥496.40 3 - - -
產(chǎn)品介紹 參考文獻(xiàn)(2篇) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties

產(chǎn)品描述： Tacrolimus monohydrate (FK506 monohydrate), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex and inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties
靶點(diǎn)： Macrolide;Phosphatase;Antibacterial;Antibiotic;Autophagy
體內(nèi)研究： The therapeutic effect of Tacrolimus is investigated on progression and perpetuation of colitis by administering Tacrolimus to Dextran sulfate sodium (DSS)-treated mice from Days 10 to 16 or to 23. At Days 17 and 24, colon length is significantly shortened, and colon weight is significantly higher in DSS-treated control animals than in normal animals. In addition, colon weight per unit length in the control group is more than twice that in the normal group. While both 7 and 14 d treatment with Tacrolimus significantly suppresses increases in colon weight per unit length in DSS-treated animals compared with the control group, this treatment does not actually restore the colon shortening. In addition, this inhibitory effect of Tacrolimus on increases in colon weight per unit length is more pronounced with 14-d than 7-d treatment, as shown by the inhibitory percentages (59% vs. 28%)
參考文獻(xiàn)： 1. Thomson AW, et al. Mode of action of Tacrolimus (FK506): molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17(6):584-91. 2. Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-γ and interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7. 3. Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886. 4. Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.
溶解性： DMSO  :  100  mg/mL  (121.65  mM;  Need  ultrasonic)    H2O  :  <  0.1  mg/mL  (ultrasonic;warming;heat  to  60°C)  (insoluble)
保存條件： -20℃
配置溶液濃度參考：
1mg 5mg 10mg
1 mM 1.217 ml 6.083 ml 12.165 ml
5 mM 0.243 ml 1.217 ml 2.433 ml
10 mM 0.122 ml 0.608 ml 1.217 ml
50 mM 0.024 ml 0.122 ml 0.243 ml
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