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Pyridostatin trifluoroacetate salt

98%

Pyridostatin trifluoroacetate salt

產(chǎn)品說明書核磁下載

品牌：源葉(MedMol)

產(chǎn)品編號(hào)：S80079 一鍵復(fù)制產(chǎn)品信息

CAS號(hào)：1472611-44-1

分子式：C₃₁H₃₂N₈O₅·xC₂HF₃O₂

分子量：596.64 (free base basis)

別名：4-(2-Aminoethoxy)-N2,N6-bis[4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinedicarboxamide trifluoroacetate salt, RR82 trifluoroacetate salt

貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京	購(gòu)買數(shù)量
S80079-5mg	98%	￥500.00 S80079-5mg ￥500.00 現(xiàn)貨	4 4	-	-	-
S80079-25mg	98%	￥1300.00 S80079-25mg ￥1300.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹參考文獻(xiàn) 質(zhì)檢證書(COA) 摩爾濃度計(jì)算器相關(guān)產(chǎn)品

產(chǎn)品介紹

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

產(chǎn)品描述：

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

靶點(diǎn)：

DNA/RNA Synthesis;DNA/RNASynthesis

細(xì)胞實(shí)驗(yàn)：

Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.

參考文獻(xiàn)：

1.Rodriguez R,etal. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10. 2.Murat P,etal.G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.Nat Chem Biol. 2014 May;10(5):358-64. 3.Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7.

溶解性：

DMSO:90 mg/mL (95.88 mM)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	0 ml	0 ml	0 ml
5 mM	0 ml	0 ml	0 ml
10 mM	0 ml	0 ml	0 ml
50 mM	0 ml	0 ml	0 ml

注意：

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參考文獻(xiàn)

質(zhì)檢證書(COA)

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