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環(huán)磷酰胺

    
BR,97%

Cyclophosphamide monohydrate

源葉
S30563 一鍵復(fù)制產(chǎn)品信息
6055-19-2
C7H15Cl2N2O2P·H2O
279.1
MFCD00149395
環(huán)磷酰胺一水物;安道生;環(huán)磷氮芥;癌得星;N,N-雙(β-氯乙基)-N',O-三次甲基磷二酰胺酸酯一水化合物;2-[N,N-雙(2-氯乙基)]-1,3,2-氧氮磷雜環(huán)己烷-2-氧化物一水合物
貨號 規(guī)格 價格 上海 北京 武漢 南京 購買數(shù)量
S30563-100mg BR,97% ¥30.00 10 - - -
S30563-1g BR,97% ¥50.00 7 - 1 2
S30563-5g BR,97% ¥90.00 >10 8 - -
S30563-25g BR,97% ¥210.00 3 1 - -
S30563-100g BR,97% ¥600.00 6 - - -
S30563-500g BR,97% ¥2500.00 2 - - -
產(chǎn)品介紹 參考文獻(59篇) 質(zhì)檢證書(COA) 摩爾濃度計算器 相關(guān)產(chǎn)品

產(chǎn)品介紹

Cyclophosphamide Monohydrate是一種氮芥類烷化劑,使烷基連接到DNA的鳥嘌呤堿基。與DNA交聯(lián),造成DNA鏈斷裂,引起突變。具有細胞毒性作用。

體外研究:Cyclophosphamide (CY)是一種化學治療劑,對免疫系統(tǒng)具有劑量依賴性雙重作用。Cyclophosphamide治療增強細胞凋亡,并降低調(diào)控T細胞的穩(wěn)態(tài)增殖。Cyclophosphamide下調(diào)GITR和FoxP3的表達,其涉及T(REGs)的抑制活性。Cyclophosphamide增加原代人肝細胞培養(yǎng)物中CYP3A4,CYP2C8,和 CYP2C9蛋白水平,從而提高培養(yǎng)的肝細胞中它們自身的4-羥基化比率。代謝活化存在下,Cyclophosphamide使Salmonella tryphimurium的堿基對取代菌株產(chǎn)生突變,但是在 E. coli顯色測試中顯示為陰性。代謝活化存在下,Cyclophosphamide能夠使各種人工培養(yǎng)的細胞中產(chǎn)生基因突變,染色體畸變,微核和姐妹染色單體互換,并且代謝活化不存在時,會產(chǎn)生姐妹染色單體互換。

體內(nèi)研究:Cyclophosphamide會使大鼠,小鼠和中國倉鼠體內(nèi)產(chǎn)生染色體損傷和微核,并且在小鼠斑點試驗和Muta小鼠轉(zhuǎn)基因lacZ構(gòu)建體中產(chǎn)生基因突變。Cyclophosphamide,以確定的順序加入到GM-CSF-分泌的,neu-表達的全細胞疫苗中,能夠增強疫苗的潛在作用以延緩neu轉(zhuǎn)基因小鼠體內(nèi)的腫瘤生長。Cyclophosphamide通過增強疫苗的功效,而不是通過對癌細胞的直接細胞溶解作用發(fā)揮它的作用。

熔點: 49-53℃
沸點: 110℃
外觀: 白色或類白色結(jié)晶或結(jié)晶性粉末
溶解性: 10mg/ml  水(溶液狀態(tài)不穩(wěn)定,需要現(xiàn)配現(xiàn)用)。
敏感性: 對熱,光,空氣敏感
儲存條件: 2-8℃
用途: 本品僅供科研,不得用于其它用途。
注意: 部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。

參考文獻(59篇)

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