貨號	規(guī)格	價格	上海	北京	武漢	南京
S89346-5mg	99.2%	￥580.00 S89346-5mg ￥580.00 現(xiàn)貨	7 7	-	-	-
S89346-10mg	99.2%	￥870.00 S89346-10mg ￥870.00 現(xiàn)貨	5 5	-	-	-
S89346-25mg	99.2%	￥1400.00 S89346-25mg ￥1400.00 現(xiàn)貨	3 3	-	-	-
S89346-100mg	99.2%	￥4300.00 S89346-100mg ￥4300.00 現(xiàn)貨	1 1	-	-	-

產(chǎn)品介紹

RU.521 (RU320521) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

產(chǎn)品描述：

RU.521 (RU320521) is a potent dsDNA inhibitor (IC50 : 700 nM), inhibition of the dsDNA pathway by RU.521 requires the presence of cGAS.

靶點：

DNA; cGAS;DNA;?cGAS

體內研究：

Treatment of primary BMDMs with RU.521 or its analogs reduced IFNB1 expression in mice, indicating their effectiveness in suppressing intrinsic DNA-dependent, constitutively-activated type I interferon expression in cells deficient of a cytoplasmic DNA exonuclease.

細胞實驗：

Small-molecule compounds were serially diluted to concentrations spanning the range tested in the response curves were added to 6.7 × 10^5 RAW-Blue macrophages plated 16h prior in 96-well dishes, then harvested 72h after compound addition. ATP was measured using CellTiter Glo Viability Assay using 50 μM Tamoxifen as a positive control for cytotoxicity. Viability values were generated using vehicle (DMSO) or the first dose as 100% and Tamoxifen as 0%. Outliers were removed.

動物實驗：

the chronically elevated levels of cytokines observed in Trex1 null mice are a consequence of constitutively activated cGAS, due to the inability to eliminate aberrantly localized self-DNA. We harvested BMDMs from 6–8-week old Trex1 -/- mice, treated them with each compound, and measured expression levels of IFNB1 by quantitative reverse transcription PCR (qRT-PCR). Treatment of primary BMDMs with RU.521 or its analogs reduced IFNB1 expression, indicating their effectiveness in suppressing intrinsic DNA-dependent, constitutively-activated type I interferon expression in cells deficient of a cytoplasmic DNA exonuclease.

參考文獻：

1. Vincent J, et al. Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun. 2017 Sep 29;8(1):750.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.408 ml	12.042 ml	24.083 ml
5 mM	0.482 ml	2.408 ml	4.817 ml
10 mM	0.241 ml	1.204 ml	2.408 ml
50 mM	0.048 ml	0.241 ml	0.482 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=10.8] Yanan Sheng et al."In situ bio-mineralized Mn nanoadjuvant enhances anti-influenza immunity of recombinant virus-like particle vaccines."JOURNAL OF CONTROLLED RELEASE".2024 Apr;368:275

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RU.521

3-(1-(6,7-Dichloro-1H-benzo[d]imidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl)isobenzofuran-1(3H)-one