貨號	規(guī)格	價格	上海	北京	武漢	南京
S88066-5mg	≥99%	￥680.00 S88066-5mg ￥680.00 2-3天	0 貨期：2-3天	-	-	-
S88066-10mg	≥99%	￥1084.00 S88066-10mg ￥1084.00 現(xiàn)貨	10 10	-	-	-
S88066-25mg	≥99%	￥2470.00 S88066-25mg ￥2470.00 2-3天	0 貨期：2-3天	-	-	-
S88066-50mg	≥99%	￥4325.00 S88066-50mg ￥4325.00 現(xiàn)貨	10 10	-	-	-
S88066-100mg	≥99%	￥6487.00 S88066-100mg ￥6487.00 現(xiàn)貨	7 7	-	-	-

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產(chǎn)品介紹

YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.

產(chǎn)品描述：

YU238259 is a novel inhibitor of homology-dependent DNA repair(HDR), but does not inhibit non-homologous end-joining (NHEJ), in cell-based GFP reporter assays.

靶點：

DNA-PK;DNA-PK;?Others

體內(nèi)研究：

Growth of BRCA2-deficient human tumor xenografts in nude mice is significantly delayed by YU238259 treatment even without concomitant DNA-damaging therapy.

細胞實驗：

U2OS cells were pretreated with 25 μM YU238259 or DMSO vehicle for 1 h and cells were then irradiated with 10 Gy IR. Cells were fixed at 8 h post-IR, stained with antibodies and Hoechst dye, and imaged. Foci were quantified using the InCell Analyzer algorithm developed by YCMD. Cells were scored as foci-positive if they contained ≥15 foci (BRCA1, pDNA-PK) or ≥20 foci (53BP1).

動物實驗：

Animal Models: 069(nu)/070(nu/+) athymic nude mice. Formulation: 3:1 DMSO:PBS. Dosages: 3 mg/kg . Administration: i.p

參考文獻：

1. Stachelek GC,etal.YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.Mol Cancer Res. 2015 Oct;13(10):1389-97.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.174 ml	10.871 ml	21.741 ml
5 mM	0.435 ml	2.174 ml	4.348 ml
10 mM	0.217 ml	1.087 ml	2.174 ml
50 mM	0.043 ml	0.217 ml	0.435 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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