貨號	規(guī)格	價格	上海	北京	武漢	南京
S87785-1mg	99.6%	￥190.00 S87785-1mg ￥190.00 現(xiàn)貨	10 10	-	-	-
S87785-5mg	99.6%	￥220.00 S87785-5mg ￥220.00 現(xiàn)貨	6 6	-	-	-
S87785-10mg	99.6%	￥310.00 S87785-10mg ￥310.00 現(xiàn)貨	6 6	-	-	-
S87785-25mg	99.6%	￥410.00 S87785-25mg ￥410.00 現(xiàn)貨	6 6	-	-	-
S87785-50mg	≥98%	￥550.00 S87785-50mg ￥550.00 2-3天	0 貨期：2-3天	-	-	-
S87785-100mg	≥98%	￥740.00 S87785-100mg ￥740.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

VU0155041 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)

產(chǎn)品描述：

靶點：

Human mGlu4:798 nM (EC50);Rat mGlu4:693 nM (EC50);GluR

體內(nèi)研究：

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].VU0155041 (93 nnmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480)-induced akinesia in rats. Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g) Dosage: 31 nmol, 93 nmol (10 μL) Administration: Intracerebroventrical injection, after the Haloperidol (1.5 mg/kg) treatment 2 hours Result: Decreased the cataleptic effects of Haloperidol, and the effects still presented 30 min after infusion.

參考文獻：

1. Niswender CM, et, al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol. 2008 Nov; 74(5): 1345-58.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.163 ml	15.814 ml	31.628 ml
5 mM	0.633 ml	3.163 ml	6.326 ml
10 mM	0.316 ml	1.581 ml	3.163 ml
50 mM	0.063 ml	0.316 ml	0.633 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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UV0155041

(±)-cis-2-(3,5-Dichlorophenylcarbamoy)cyclohexanecarboxylic Acid