貨號	規(guī)格	價格	上海	北京	武漢	南京
S86548-1mg	98.7%	￥210.80 S86548-1mg ￥210.80 現(xiàn)貨	5 5	-	-	-
S86548-2mg	98.7%	￥380.80 S86548-2mg ￥380.80 現(xiàn)貨	5 5	-	-	-
S86548-5mg	98.7%	￥680.00 S86548-5mg ￥680.00 現(xiàn)貨	5 5	-	-	-
S86548-10mg	98.7%	￥1156.00 S86548-10mg ￥1156.00 現(xiàn)貨	6 6	-	-	-
S86548-25mg	98.7%	￥1600.00 S86548-25mg ￥1600.00 現(xiàn)貨	4 4	-	-	-
S86548-50mg	≥98%	￥2750.00 S86548-50mg ￥2750.00 2-3天	0 貨期：2-3天	-	-	-
S86548-100mg	≥98%	￥4000.00 S86548-100mg ￥4000.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM

產(chǎn)品描述：

TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM

靶點：

IC50: 40 nM (recombinant SHP-1);Phosphatase;GlucocorticoidReceptor

體外研究：

SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ+ cells and induces IFNγ+ cells in human peripheral blood

體內(nèi)研究：

TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ+ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent

參考文獻：

1. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.951 ml	19.757 ml	39.513 ml
5 mM	0.79 ml	3.951 ml	7.903 ml
10 mM	0.395 ml	1.976 ml	3.951 ml
50 mM	0.079 ml	0.395 ml	0.79 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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