貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S86364-5mg	≥98%	￥2320.00 S86364-5mg ￥2320.00 2-3天	0 貨期：2-3天	-	-	-
S86364-10mg	≥98%	￥3550.00 S86364-10mg ￥3550.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay

產(chǎn)品描述：

360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay

靶點(diǎn)：

IC50: 300 nM (Telomerase) G-quadruplex;Telomerase

體外研究：

360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300 nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions

參考文獻(xiàn)：

1. Pennarun G, et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene. 2005 Apr 21;24(18):2917-28. 2. Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.422 ml	7.109 ml	14.218 ml
5 mM	0.284 ml	1.422 ml	2.844 ml
10 mM	0.142 ml	0.711 ml	1.422 ml
50 mM	0.028 ml	0.142 ml	0.284 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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360A (iodide)