貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S86339-1mg	99.6%	￥120.00 S86339-1mg ￥120.00 現(xiàn)貨	9 9	-	-	-
S86339-2mg	99.6%	￥190.00 S86339-2mg ￥190.00 現(xiàn)貨	7 7	-	-	-
S86339-5mg	99.6%	￥320.00 S86339-5mg ￥320.00 現(xiàn)貨	7 7	-	-	-
S86339-10mg	99.6%	￥590.00 S86339-10mg ￥590.00 現(xiàn)貨	6 6	-	-	-
S86339-25mg	99.6%	￥990.00 S86339-25mg ￥990.00 現(xiàn)貨	5 5	-	-	-
S86339-50mg	≥99%	￥1400.00 S86339-50mg ￥1400.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid

產(chǎn)品描述：

靶點(diǎn)：

p38 MAPK;p38MAPK;TNF

體內(nèi)研究：

SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity

參考文獻(xiàn)：

1. Frasch SC, et al. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97. 2. Griswold DE, et al. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70. 3. Lee JC, et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature. 1994;372(6508):739-746. 4. L A Marshall, et al. Inhibitors of the p38 mitogen-activated kinase modulate IL-4 induction of low affinity IgE receptor (CD23) in human monocytes. J Immunol. 1998 Dec 1;161(11):6005-13. 5. M J DiMartino, et al. Pharmacologic characterization of the antiinflammatory properties of a new dual inhibitor of lipoxygenase and cyclooxygenase. Agents Actions. 1987 Feb;20(1-2):113-23.

溶解性：

Soluble in DMSO

保存條件：

2-8℃，避光

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.363 ml	16.815 ml	33.629 ml
5 mM	0.673 ml	3.363 ml	6.726 ml
10 mM	0.336 ml	1.681 ml	3.363 ml
50 mM	0.067 ml	0.336 ml	0.673 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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SKF-86002

6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE