產(chǎn)品描述: | Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma |
靶點(diǎn): |
Human Endogenous Metabolite;OxytocinReceptor |
體內(nèi)研究: |
During the LMA task, rat core body temperature are modestly decreased. Oxytocin acetate (subcutaneous injection; 0.1?mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3?mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60?min post injection, whereas 0.1?mg/kg slightly decreases temperature at the 30?min time point only. Oxytocin acetate (0.1?mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3?s), compared to those receiving vehicle (56.9±4.1?s) |
參考文獻(xiàn): |
1. Shivali Kohli, et al. Oxytocin attenuates phencyclidine hyperactivity and increases social interaction and nucleus accumben dopamine release in rats. Neuropsychopharmacology. 2019 Jan;44(2):295-305. 2. C Sue Carter, et al. Is Oxytocin Nature's Medicine ? Pharmacol Rev. 2020 Oct;72(4):829-861. |
溶解性: |
Soluble in DMSO、H2O |
保存條件: |
-20℃ |
配置溶液濃度參考: |
|
1mg |
5mg |
10mg |
1 mM |
0.937 ml |
4.685 ml |
9.37 ml |
5 mM |
0.187 ml |
0.937 ml |
1.874 ml |
10 mM |
0.094 ml |
0.468 ml |
0.937 ml |
50 mM |
0.019 ml |
0.094 ml |
0.187 ml |
|
注意: |
部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。 |