產(chǎn)品描述: | Angiotensin II 5-valine is an agonist of angiotensin receptor. |
靶點: |
Angiotensin receptor;RAAS |
體內(nèi)研究: |
By day 12, systolic blood pressure (SBP) increases significantly in Angiotensin II 5-valine infused rats (197±7 mm Hg). As shown, the development of hypertension in ANG II infused rats is prevented by losartan treatment. Blood and kidney samples are harvested, subjected to HPLC to separate Angiotensin II 5-valine (exogenous) from Ile5-ANG II (endogenous) and the fractions are measured by radioimmunoassay. In the Angiotensin II 5-valine infused rats treated with losartan, total plasma ANG II levels are elevated to a greater extent than in rats not treated with losartan (289±20 v 119±14 fmol/mL). However, losartan markedly decrease by 88% the enhancement of intrarenal Val5-ANG II content that occurred in the rats infused with Val5-ANG II alone |
參考文獻: |
1. Zou LX et al. Renal uptake of circulating angiotensin II in Val5-angiotensin II infused rats is mediated by AT1 receptor. Am J Hypertens. 1998 May;11(5):570-8. |
溶解性: |
Soluble in H2O |
保存條件: |
-20°C |
配置溶液濃度參考: |
|
1mg |
5mg |
10mg |
1 mM |
0.969 ml |
4.844 ml |
9.689 ml |
5 mM |
0.194 ml |
0.969 ml |
1.938 ml |
10 mM |
0.097 ml |
0.484 ml |
0.969 ml |
50 mM |
0.019 ml |
0.097 ml |
0.194 ml |
|
注意: |
部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。 |