貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S85596-1mg	98.7%	￥70.00 S85596-1mg ￥70.00 現(xiàn)貨	9 9	-	-	-
S85596-2mg	98.7%	￥120.00 S85596-2mg ￥120.00 現(xiàn)貨	8 8	-	-	-
S85596-5mg	98.7%	￥170.00 S85596-5mg ￥170.00 現(xiàn)貨	8 8	-	-	-
S85596-10mg	98.7%	￥290.00 S85596-10mg ￥290.00 現(xiàn)貨	6 6	-	-	-
S85596-25mg	98.7%	￥500.00 S85596-25mg ￥500.00 現(xiàn)貨	5 5	-	-	-
S85596-50mg	98.7%	￥740.00 S85596-50mg ￥740.00 現(xiàn)貨	5 5	-	-	-
S85596-100mg	≥98%	￥1050.00 S85596-100mg ￥1050.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.

產(chǎn)品描述：

IRAK-1-4 Inhibitor I is a dual inhibitor of IRAK4 and IRAK1.

靶點(diǎn)：

IRAK

細(xì)胞實(shí)驗(yàn)：

IRAK-1-4 Inhibitor I is dissolved in DMSO and stored, and then diluted with appropriate media before use. NCM460 cells, grown in 24-well plates, are incubated with 50 μM IRAK-1/4 inhibitor for 2 h. After 2 h, the media are changed, and new media with or without LPS (10 ng/mL) added. Treatment is terminated at 6 h, and spent media and cells are collected for IL-8 and other assays

參考文獻(xiàn)：

1.Powers JP, et al. Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-2845. 2.Bhattacharyya S, et al. Bcl10 mediates LPS-induced activation of NF-kappaB and IL-8 in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37. 3.Wu X, Xu M, Liu Y, et al. Dual Pharmacological Inhibition of IRAK1 and IRAK4 Prevents LPS Induced Monocyte Adhesion to Endothelial Cells[J]. bioRxiv. 2021

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.529 ml	12.645 ml	25.29 ml
5 mM	0.506 ml	2.529 ml	5.058 ml
10 mM	0.253 ml	1.264 ml	2.529 ml
50 mM	0.051 ml	0.253 ml	0.506 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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IRAK-1/4 INHIBITOR I