貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S85282-5mg	≥99%	￥2130.00 S85282-5mg ￥2130.00 2-3天	0 貨期：2-3天	-	-	-
S85282-10mg	≥99%	￥3300.00 S85282-10mg ￥3300.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity

產(chǎn)品描述：

靶點：

α4β1;α4β7;Integrin

體內(nèi)研究：

Firategrast (30?mg/kg/day in drinking water; starting 2 or 7 days post transplantation to 21 days) shows an overall reduction of leukemic cells in the spleen Animal Model: Female Wild-type C57BL/6J mice (8-12 weeks) with primary TCL1-tg splenocytes Dosage: 30?mg/kg Administration: Drinking water; daily; starting 2 or 7 days post transplantation to 21 days Result: Showed an overall reduction of leukemic cells in the spleen, accompanied by significant spleen weight reduction.

參考文獻：

1. Moses O. Evbuomwan, et al. Generation and Characterization of Novel VLA-4 Inhibitors for Stem Cell Mobilization in Combination with a CXCR2 Agonist. Blood (2017) 130 (Supplement 1): 3197. 2. Sarah E M Herman, et al. Treatment with Ibrutinib Inhibits BTK- and VLA-4-Dependent Adhesion of Chronic Lymphocytic Leukemia Cells In Vivo. Clin Cancer Res. 2015 Oct 15;21(20):4642-51. 3. Eva Szenes, et al. TCL1 transgenic mice as a model for CD49d-high chronic lymphocytic leukemia. Leukemia. 2020 Sep;34(9):2498-2502. 4. H Rahimi, et al. Aberrant regulation of the integrin very late antigen-4 in systemic lupus erythematosus. Lupus. 2013 Mar;22(3):297-306.

溶解性：

Soluble in DMSO、Ethanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.002 ml	10.01 ml	20.02 ml
5 mM	0.4 ml	2.002 ml	4.004 ml
10 mM	0.2 ml	1.001 ml	2.002 ml
50 mM	0.04 ml	0.2 ml	0.4 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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