貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S84573-5mg	98.8%	￥790.00 S84573-5mg ￥790.00 現(xiàn)貨	13 >10	-	-	-
S84573-10mg	98.8%	￥1180.00 S84573-10mg ￥1180.00 現(xiàn)貨	13 >10	-	-	-

產(chǎn)品介紹

VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.

產(chǎn)品描述：

VAL-083 is an alkylating agent that creates N7 methylation on DNA, with antitumor activity.

靶點：

DNA Alkylator;DNAAlkylator/Crosslinker;?DNAAlkylation

體內(nèi)研究：

VAL-083 (Dianhydrogalactitol; 25, 50, 100 μg/mL) dose-dependently inhibits angiogenesis in zebrafish model. VAL-083 considerably reduces VEGF, VEGFR2, and FGF2 expression at 25 μg/mL, and further causes reduction in FGFR2 expression at 50 μg/mL. VAL-083 (1,2:5,6-dianhydrogalactitol; 5 mg/kg, iv, twice per week for 6 weeks) significantly blocks the growth of LN229 cells in mice with the relative tumor growth rate (T/C) of 22.38%, and the tumor growth inhibitory rate (TGI) of 83.58%. Moreover, VAL-083 dramatically activates the CDC25C-CDK1 cascade in the xenografted tumor moedl

參考文獻：

1. Kaiji Hu, et al. Abstract 811: VAL083, a novel N7 alkylating agent, surpasses NSC 362856 activity and inhibits cancer stem cells providing a new potential treatment option for glioblastoma multiforme. Cancer Research. 2012 Mar 31-Apr 4. 2. Jiang X, et al. Dianhydrogalactitol, a potential multitarget agent, inhibits glioblastoma migration, invasion, and angiogenesis. Biomed Pharmacother. 2017 Jul;91:1065-1074. 3. Peng C, et al. 1,2:5,6-dianhydrogalactitol inhibits human glioma cell growth in vivo and in vitro by arresting the cell cycle at G2/M phase. Acta Pharmacol Sin. 2017 Apr;38(4):561-570.

溶解性：

DMSO : 200 mg/mL (1368.55 mM; ultrasonic and warming and heat to 60°C) DMF : ≥ 100 mg/mL (684.28 mM) H2O : 50 mg/mL (342.14 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	6.843 ml	34.214 ml	68.428 ml
5 mM	1.369 ml	6.843 ml	13.686 ml
10 mM	0.684 ml	3.421 ml	6.843 ml
50 mM	0.137 ml	0.684 ml	1.369 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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