| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
S83773-1mg |
99.9% | ￥212.00 | 9 | - | - | - |
|
S83773-2mg |
99.9% | ￥365.00 | 8 | - | - | - |
|
S83773-5mg |
99.9% | ￥671.00 | 8 | - | - | - |
|
S83773-10mg |
99.9% | ￥1062.00 | 6 | - | - | - |
|
S83773-25mg |
99.9% | ￥1530.00 | 5 | - | - | - |
|
S83773-50mg |
99.9% | ￥2450.00 | 4 | - | - | - |
|
S83773-100mg |
99.9% | ￥4200.00 | 5 | - | - | - |
|
YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM
| 產(chǎn)品描述： | YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM | ||||||||||||||||||||
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| 靶點： | IL-5;ILReceptor;?Interleukin | ||||||||||||||||||||
| 體內(nèi)研究： | YM-90709 (0.01-10 mg/kg; intravenous injection, 72 hours, Inbred female Brown-Norway (BN) rats) results in the inhibition of antigen-induced infiltration of eosinophils and lymphocytes, but not neutrophils or monocytes, into the bronchoalveolar lavage fluid (BALF) of Brown-Norway (BN) rats | ||||||||||||||||||||
| 參考文獻： | 1. Morokata T, et al. Characterization of YM-90709 as a novel antagonist which inhibits the binding of interleukin-5 to interleukin-5 receptor. Int Immunopharmacol. 2002 Nov;2(12):1693-702. 2. Morokata T, et al. Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice. Immunol Lett. 2005 Apr 15;98(1):161-5. | ||||||||||||||||||||
| 溶解性： | DMSO : 62.5 mg/mL (173.89 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存條件： | RT | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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北京