貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83671-2mg	≥98%	￥770.00 S83671-2mg ￥770.00 2-3天	0 貨期：2-3天	-	-	-
S83671-5mg	≥98%	￥1110.00 S83671-5mg ￥1110.00 2-3天	0 貨期：2-3天	-	-	-
S83671-10mg	≥98%	￥1950.00 S83671-10mg ￥1950.00 2-3天	0 貨期：2-3天	-	-	-
S83671-25mg	≥98%	￥3900.00 S83671-25mg ￥3900.00 2-3天	0 貨期：2-3天	-	-	-
S83671-50mg	≥98%	￥6200.00 S83671-50mg ￥6200.00 2-3天	0 貨期：2-3天	-	-	-
S83671-100mg	≥98%	￥10500.00 S83671-100mg ￥10500.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of ?7.62.

產(chǎn)品描述：

GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of ?7.62.

靶點(diǎn)：

logEC50: ?7.62;GPR

體外研究：

GPR120 Agonist 3 is fully selective for Gpr120 (logEC50=?7.62) with negligible activity towards Gpr40. GPR120 Agonist 3 produces concentration dependent increases in IP3 production from both human and mouse Gpr120 expressing cells. GPR120 Agonist 3 leads to a concentration-dependent response to recruit β-arrestin-2 in both human and mouse Gpr120 expressing cells, with EC50s of ~0.35 μM. GPR120 Agonist 3 strongly and comparably inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk and blocked IκB degradation

體內(nèi)研究：

GPR120 Agonist 3 causes improved insulin sensitivity with increased glucose infusion rates, enhanced insulin stimulated-glucose disposal rate, along with a marked increase in the ability of insulin to suppress hepatic glucose production only in WT mice. GPR120 Agonist 3 treatment has beneficial effects on hepatic lipid metabolism, causing decreased hepatic steatosis, decreased liver triglycerides, and DAGs, along with reduced saturated free fatty acid conten

參考文獻(xiàn)：

1. Oh DY, et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nat Med. 2014 Aug;20(8):942-7.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.464 ml	12.32 ml	24.64 ml
5 mM	0.493 ml	2.464 ml	4.928 ml
10 mM	0.246 ml	1.232 ml	2.464 ml
50 mM	0.049 ml	0.246 ml	0.493 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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GPR120-IN-1