貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83116-1mg	≥98%	￥180.00 S83116-1mg ￥180.00 現(xiàn)貨	500 >10	-	-	-
S83116-2mg	≥98%	￥250.00 S83116-2mg ￥250.00 現(xiàn)貨	250 >10	-	-	-
S83116-5mg	≥98%	￥510.00 S83116-5mg ￥510.00 現(xiàn)貨	100 >10	-	-	-
S83116-10mg	≥98%	￥870.00 S83116-10mg ￥870.00 現(xiàn)貨	50 >10	-	-	-
S83116-25mg	≥98%	￥1740.00 S83116-25mg ￥1740.00 現(xiàn)貨	20 >10	-	-	-
S83116-50mg	≥98%	￥2180.00 S83116-50mg ￥2180.00 現(xiàn)貨	10 10	-	-	-
S83116-100mg	≥98%	￥3280.00 S83116-100mg ￥3280.00 現(xiàn)貨	5 5	-	-	-

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產(chǎn)品介紹

Ibiglustat (Venglustat) is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. Ibiglustat can be used for the research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease

產(chǎn)品描述：

靶點(diǎn)：

Glucosylceramide synthase;Transferase

體外研究：

Ibiglustat (SAR402671) (1 μM, 15 days; Fabry disease (FD) cells) is close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes

參考文獻(xiàn)：

1. Viel C, et al. Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model. Sci Rep. 2021;11(1):20945. Published 2021 Oct 22. 2. Peterschmitt MJ, et al. Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Oral Venglustat in Healthy Volunteers. Clin Pharmacol Drug Dev. 2021;10(1):86-98. 3. Stojkovska I, et al. Molecular mechanisms of α-synuclein and GBA1 in Parkinson's disease. Cell Tissue Res. 2018;373(1):51-60. 4. Itier JM, et al. Effective clearance of GL-3 in a human iPSC-derived cardiomyocyte model of Fabry disease. J Inherit Metab Dis. 2014 Nov;37(6):1013-22.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.567 ml	12.837 ml	25.675 ml
5 mM	0.513 ml	2.567 ml	5.135 ml
10 mM	0.257 ml	1.284 ml	2.567 ml
50 mM	0.051 ml	0.257 ml	0.513 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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