貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S83083-5mg	≥98%	￥350.00 S83083-5mg ￥350.00 2-3天	0 貨期：2-3天	-	-	-
S83083-10mg	≥98%	￥660.00 S83083-10mg ￥660.00 2-3天	0 貨期：2-3天	-	-	-
S83083-50mg	≥98%	￥2800.00 S83083-50mg ￥2800.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride), a inhibitory neurotransmitter GABA vinyl-derivative, is an orally active and irreversible GABA transaminase inhibitor. Vigabatrin hydrochloride is an antiepileptic agent, which acts by increasing GABA levels in the brain by inhibiting the catabolism of GABA by GABA transaminase

產(chǎn)品描述：

靶點(diǎn)：

GABA Receptor;GABAReceptor

體內(nèi)研究：

Vigabatrin inhibits the uptake of taurine in Caco-2 and MDCK cells to 34% and 53%, respectively, at a concentration of 30 mM. In Caco-2 cells the uptake of Vigabatrin under neutral pH conditions is concentration-dependent and saturable with a Km-value of 27 mM. Vigabatrin is able to inhibit the uptake of taurine in intestinal and renal cell culture models

參考文獻(xiàn)：

1. Broeer, et al. Vigabatrin for focal drug delivery in epilepsy: Bilateral microinfusion into the subthalamic nucleus is more effective than intranigral or systemic administration in a rat seizure model. Neurobiology of Disease (2012), 46(2), 362-376. 2. Jakob Plum, et al. The anti-epileptic drug substance vigabatrin inhibits taurine transport in intestinal and renal cell culture models. Int J Pharm. 2014 Oct 1;473(1-2):395-7. 3. Gaily, Eija Vigabatrin monotherapy for infantile spasms. Expert Review of Neurotherapeutics (2012), 12(3), 275-286.

溶解性：

Soluble in DMSO、H2O

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	6.038 ml	30.19 ml	60.379 ml
5 mM	1.208 ml	6.038 ml	12.076 ml
10 mM	0.604 ml	3.019 ml	6.038 ml
50 mM	0.121 ml	0.604 ml	1.208 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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rac-Vigabatrin Hydrochloride