貨號	規(guī)格	價格	上海	北京	武漢	南京
S82846-1mg	98.2%	￥503.20 S82846-1mg ￥503.20 現(xiàn)貨	6 6	-	-	-
S82846-2mg	98.2%	￥714.00 S82846-2mg ￥714.00 現(xiàn)貨	7 7	-	-	-
S82846-5mg	98.2%	￥986.00 S82846-5mg ￥986.00 現(xiàn)貨	7 7	-	-	-
S82846-10mg	98.2%	￥1564.00 S82846-10mg ￥1564.00 現(xiàn)貨	7 7	-	-	-
S82846-25mg	98.2%	￥2788.00 S82846-25mg ￥2788.00 現(xiàn)貨	5 5	-	-	-
S82846-50mg	≥98%	￥4828.00 S82846-50mg ￥4828.00 2-3天	0 貨期：2-3天	-	-	-
S82846-100mg	≥98%	￥7700.00 S82846-100mg ￥7700.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

產(chǎn)品描述：

NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.

靶點：

IC50: 5.74 μM (NOD1), 6.45 μM (NOD2);NOD-likeReceptor(NLR);?NOD

體外研究：

NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets

參考文獻(xiàn)：

1. Kecek Plesec K, et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.912 ml	14.56 ml	29.121 ml
5 mM	0.582 ml	2.912 ml	5.824 ml
10 mM	0.291 ml	1.456 ml	2.912 ml
50 mM	0.058 ml	0.291 ml	0.582 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

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