貨號	規(guī)格	價格	上海	北京	武漢	南京
S82780-5mg	99.9%	￥208.00 S82780-5mg ￥208.00 現(xiàn)貨	1 1	-	-	-
S82780-10mg	99.9%	￥360.00 S82780-10mg ￥360.00 現(xiàn)貨	6 6	-	-	-
S82780-25mg	99.9%	￥680.00 S82780-25mg ￥680.00 現(xiàn)貨	1 1	-	-	-
S82780-50mg	99.9%	￥1120.00 S82780-50mg ￥1120.00 現(xiàn)貨	7 7	-	-	-
S82780-100mg	99.9%	￥1680.00 S82780-100mg ￥1680.00 現(xiàn)貨	3 3	-	-	-

產(chǎn)品介紹

Entacapone (OR-611) 抑制兒茶酚-O-甲基轉(zhuǎn)移酶(COMT)活性，IC50為151 nM。Entacapone 是一種 FTO demethylation 的抑制劑，IC50為3.5 μM，可用于代謝紊亂的研究

產(chǎn)品描述：

Entacapone (OR-611) 抑制兒茶酚-O-甲基轉(zhuǎn)移酶(COMT)活性，IC50為151 nM。Entacapone 是一種 FTO demethylation 的抑制劑，IC50為3.5 μM，可用于代謝紊亂的研究

靶點：

COMT:151 nM;Transferase

體外研究：

Entacapone在不同組織中抑制catechol-O-methyltransferase(COMT)的IC50值大體相似，包括肝臟，十二指腸, 腎臟和肺, 但是entacapone在這些組織中抑制效果比tolcapone更好。 Entacapone (< 100 μM)可以有效抑制α-syn和β-amyloid (Aβ) 齊聚反應(yīng)和原纖維生成同時可以保護PC12細胞免受這兩種蛋白聚集誘導的細胞外毒性

體內(nèi)研究：

Entacapone administration reduced body weight and lowered fasting blood glucose concentrations in diet-induced obese mice.

細胞實驗：

Cell lines: PC12 cells Concentrations: 5 μM Incubation Time: 72 h Method: Cells were treated with various concentrations of drug for 72 h.

動物實驗：

Animal Models: Male C57BL/6 mice Dosages: 600 mg/kg Administration: p.o.

參考文獻：

1. De Santi C, et al. Catechol-O-methyltransferase: variation in enzyme activity and inhibition by entacapone and tolcapone. Eur J Clin Pharmacol, 1998, 54(3), 215-219. 2. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem, 2010, 285(20), 14941-14954. 3. Jenner P, et al. Avoidance of dyskinesia: preclinical evidence for continuous dopaminergic stimulation. Neurology, 2004, 62(1 Suppl 1), S47-55. 4. Hamaue N, et al. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain Res, 2010, 1309, 110-115. 5. Peng S, et al. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med. 2019 Apr 17;11(488):eaa

溶解性：

Soluble in DMSO、Ethanol

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.276 ml	16.378 ml	32.756 ml
5 mM	0.655 ml	3.276 ml	6.551 ml
10 mM	0.328 ml	1.638 ml	3.276 ml
50 mM	0.066 ml	0.328 ml	0.655 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(3篇)

3. [IF=2.9] Nan Zhang et al."N6-methyladenosine mediated-NRF2 signaling pathway attenuates cadmium cytotoxicity by inhibiting oxidative damage in bronchial epithelial cells."TOXICOLOGY LETTERS.2025 Jan;403:144 2. [IF=4.8] Guofen Liu et al."Roles of N6-methyladenosine in LncRNA changes and oxidative damage in cadmium-induced pancreatic β-cells."TOXICOLOGY.2025 Feb;511:154053 1. [IF=6.2] Yifei Sun et al."Roles of m6A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death."ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY.2024 Sep;282:116672

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