貨號	規(guī)格	價格	上海	北京	武漢	南京
S82514-1mg	≥99%	￥650.00 S82514-1mg ￥650.00 2-3天	0 貨期：2-3天	-	-	-
S82514-2mg	≥99%	￥950.00 S82514-2mg ￥950.00 2-3天	0 貨期：2-3天	-	-	-
S82514-5mg	≥99%	￥1530.00 S82514-5mg ￥1530.00 2-3天	0 貨期：2-3天	-	-	-
S82514-10mg	≥99%	￥2300.00 S82514-10mg ￥2300.00 2-3天	0 貨期：2-3天	-	-	-
S82514-50mg	≥99%	￥9000.00 S82514-50mg ￥9000.00 2-3天	0 貨期：2-3天	-	-	-
S82514-100mg	≥99%	￥15000.00 S82514-100mg ￥15000.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC50=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research

產(chǎn)品描述：

靶點：

IC50: 0.31 μM (LeuRS);Antibacterial

體外研究：

Epetraborole (0-32 μg/mL) shows anti-bacterial activity against key gram-negative aerobic and anaerobic pathogens and gram-positive anaerobes. Cell Viability Assay Cell Line: Anaerobes isolates Concentration: 0-32 μg/mL Incubation Time: Result: Showed MIC50/MIC90 for all anaerobes isolates tested of 2 and 4 μg/mL, respectively.

參考文獻：

1. Goldstein EJ, et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms. Antimicrob Agents Chemother. 2013 May;57(5):2401-4. 2. O'Dwyer K, et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98. 3. Sutcliffe JA. Antibiotics in development targeting protein synthesis. Ann N Y Acad Sci. 2011 Dec;1241:122-52.

溶解性：

Soluble in DMSO、H2O

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.656 ml	18.28 ml	36.56 ml
5 mM	0.731 ml	3.656 ml	7.312 ml
10 mM	0.366 ml	1.828 ml	3.656 ml
50 mM	0.073 ml	0.366 ml	0.731 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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Epetraborole (hydrochloride)