| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數量 |
|---|---|---|---|---|---|---|---|
S81948-1mg |
≥97% | ￥340.00 | 貨期：2-3天 | - | - | - |
|
S81948-5mg |
≥97% | ￥820.00 | 貨期：2-3天 | - | - | - |
|
S81948-10mg |
≥97% | ￥1400.00 | 貨期：2-3天 | - | - | - |
|
S81948-25mg |
≥97% | ￥2900.00 | 貨期：2-3天 | - | - | - |
|
S81948-50mg |
≥97% | ￥5600.00 | 貨期：2-3天 | - | - | - |
|
S81948-100mg |
≥97% | ￥10800.00 | 貨期：2-3天 | - | - | - |
|
Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively.
| 產品描述： | Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM, 1 nM, and 0.3 nM for B-RafWT, B-RafV600E, and C-Raf, respectively. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | B-Raf:1 nM (Ki);B-RafV600E:1 nM (Ki);c-Raf:0.3 nM (Ki);Raf | ||||||||||||||||||||
| 體外研究： | Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC50s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers | ||||||||||||||||||||
| 參考文獻： | 1. Wang X, et al. Conformation-specific effects of Raf kinase inhibitors. J Med Chem. 2012 Sep 13;55(17):7332-41. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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危險品化學品經營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京