| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
S81753-1mg |
99.9% | ￥190.00 | 5 | - | - | - |
|
S81753-2mg |
99.9% | ￥245.00 | 5 | - | - | - |
|
S81753-5mg |
99.9% | ￥290.00 | 5 | - | - | - |
|
S81753-10mg |
99.9% | ￥430.00 | 6 | - | - | - |
|
S81753-25mg |
99.9% | ￥650.00 | 6 | - | - | - |
|
S81753-50mg |
≥98% | ￥1100.00 | 貨期：2-3天 | - | - | - |
|
GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor.
| 產(chǎn)品描述： | GNE-477 is a potent and efficacious dual PI3K (IC50=4 nM)/mTOR(Ki=21 nM) inhibitor. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | PI3Kα:4 nM (IC50);mTOR:21 nM (Ki);PI3K;?mTOR | ||||||||||||||||||||
| 體外研究： | GNE-477 (Compound 8) has improved potency in the MCF7.1 cell proliferation assay with an EC50 of 143 nM | ||||||||||||||||||||
| 體內(nèi)研究： | GNE-477 also exhibits stasis in a PC3 tumor growth inhibition study. In an experiment evaluating the tumor growth inhibition of a PC3 tumor xenograft over 14 days, stasis is achieved at a 20 mg/kg QD dose and significant inhibition is observed with doses as low as 1 mg/kg QD. GNE-477 is generally well tolerated during this study as demonstrated by acceptable levels of weight loss comparable to that observed with the animals in the vehicle cohort | ||||||||||||||||||||
| 參考文獻： | 1. Heffron TP, et al. Identification of GNE-477, a potent and efficacious dual PI3K/mTOR inhibitor. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2408-11. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
|
||||||||||||||||||||
| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網(wǎng)安備 31011702002021號
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京