貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S81552-1mg	99.8%	￥240.00 S81552-1mg ￥240.00 現(xiàn)貨	5 5	-	-	-
S81552-5mg	99.8%	￥424.00 S81552-5mg ￥424.00 現(xiàn)貨	7 0 7	-	-	-
S81552-10mg	99.8%	￥720.00 S81552-10mg ￥720.00 現(xiàn)貨	6 6	-	-	-
S81552-25mg	99.8%	￥1440.00 S81552-25mg ￥1440.00 現(xiàn)貨	4 4	-	-	-
S81552-50mg	≥99%	￥2560.00 S81552-50mg ￥2560.00 2-3天	0 貨期：2-3天	-	-	-
S81552-100mg	≥99%	￥4000.00 S81552-100mg ￥4000.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).

產(chǎn)品描述：

BI-78D3 functions as a substrate competitive inhibitor of JNK, inhibit the JNK kinase activity (IC50=280 nM).

靶點(diǎn)：

JNK:280 nM (IC50);JNK

體內(nèi)研究：

The link between ConA-induced liver failure, TNF receptor signaling, and JNK function has been established by studies employing JNK1-/-?and JNK2-/-?mice. For this analysis, insulin insensitive mice are injected only once with 25 mg/kg BI-78D3, 30 min before insulin injection. The effect of insulin on blood glucose levels is then measured. BI-78D3 results in a statistically significant reduction in blood glucose levels as compared with the vehicle control. Thus, the ability of BI-78D3 to abrogate ConA-induced liver damage and restore insulin sensitivity is consistent with its proposed function as an effective JNK inhibitor. Liquid chromatography/mass spectrometry bio-availability analysis demonstrates that BI-78D3 has favorable microsome and plasma stability (T1/2=54 min)

參考文獻(xiàn)：

1. Stebbins JL et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc Natl Acad Sci U S A, 2008 Oct 28, 105(43):16809-13.

溶解性：

DMSO : 100 mg/mL (263.59 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.639 ml	13.193 ml	26.385 ml
5 mM	0.528 ml	2.639 ml	5.277 ml
10 mM	0.264 ml	1.319 ml	2.639 ml
50 mM	0.053 ml	0.264 ml	0.528 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(COA)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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BI-78D3

4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one