貨號	規(guī)格	價格	上海	北京	武漢	南京
S81232-2mg	99.1%	￥100.00 S81232-2mg ￥100.00 現(xiàn)貨	5 5	-	-	-
S81232-5mg	99.1%	￥170.00 S81232-5mg ￥170.00 現(xiàn)貨	6 6	-	-	-
S81232-10mg	99.1%	￥320.00 S81232-10mg ￥320.00 現(xiàn)貨	6 6	-	-	-
S81232-25mg	99.1%	￥430.00 S81232-25mg ￥430.00 現(xiàn)貨	6 6	-	-	-
S81232-50mg	≥99%	￥620.00 S81232-50mg ￥620.00 2-3天	0 貨期：2-3天	-	-	-
S81232-100mg	≥99%	￥860.00 S81232-100mg ￥860.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

產(chǎn)品描述：

AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

靶點：

Apoptosis;Autophagy;Pim;Apoptosis;?Pim;?Autophagy

體內(nèi)研究：

AZD1208在培養(yǎng)的MOLM-16細(xì)胞中引起細(xì)胞周期停滯和細(xì)胞凋亡。這伴隨著BAD,4EBP1和p70S6K磷酸化的劑量依賴性降低。另外,AZD1208導(dǎo)致有效抑制來自骨髓抽吸物的原代AML細(xì)胞的集落生長并下調(diào)Pim靶標(biāo)的磷酸化

細(xì)胞實驗：

AZD1208 is dissolved in DMSO. MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37?C and reading of fluorescence on a Tecan Infinite? 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.

參考文獻：

1.Erika Keeton, et al. 53rd ASH Annual Meeting (2011) Abstract nr 1540

溶解性：

DMSO:7.6 mg/mL (20 mM)),with gentle warming

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.635 ml	13.176 ml	26.352 ml
5 mM	0.527 ml	2.635 ml	5.27 ml
10 mM	0.264 ml	1.318 ml	2.635 ml
50 mM	0.053 ml	0.264 ml	0.527 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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