貨號	規(guī)格	價格	上海	北京	武漢	南京
S81151-5mg	97.5%	￥190.40 S81151-5mg ￥190.40 現(xiàn)貨	9 9	-	-	-
S81151-10mg	97.5%	￥306.00 S81151-10mg ￥306.00 現(xiàn)貨	7 7	-	-	-
S81151-25mg	97.5%	￥714.00 S81151-25mg ￥714.00 現(xiàn)貨	7 7	-	-	-
S81151-50mg	97.5%	￥952.00 S81151-50mg ￥952.00 現(xiàn)貨	6 6	-	-	-
S81151-100mg	97.5%	￥1836.00 S81151-100mg ￥1836.00 現(xiàn)貨	4 4	-	-	-
S81151-200mg	≥97%	￥3536.00 S81151-200mg ￥3536.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter

產(chǎn)品描述：

靶點：

Nav1.8:8 nM (IC50);SodiumChannel

體內(nèi)研究：

A-803467 (35 mg/kg; p.o.) shows no noticeable toxicity in the male NCR nude mice. A-803467 in combination with topotecan, significantly decreases the tumor growth in mice implanted with ABCG2 overexpressing H460/MX20 cells. A-803467 effectively restores the sensitivity of tumors overexpressing ABCG2 transporter to topotecan without having any significant effect on tumors lacking ABCG2 expression.

參考文獻：

1. Anreddy N, et al. A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo. Oncotarget. 2015;6(36):39276-39291. 2. Jarvis MF, et al. A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci U S A. 2007;104(20):8520-8525.

溶解性：

DMSO : 50 mg/mL (139.75 mM; Need ultrasonic)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.795 ml	13.975 ml	27.949 ml
5 mM	0.559 ml	2.795 ml	5.59 ml
10 mM	0.279 ml	1.397 ml	2.795 ml
50 mM	0.056 ml	0.279 ml	0.559 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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A-803467

5-(4-chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide