產(chǎn)品描述: | Procarbazine Hydrochloride is an orally active alkylating agent, with anticancer activity. Procarbazine Hydrochloride can be used in Hodgkin's disease research |
靶點(diǎn): |
DNA Alkylator/Crosslinker;DNAAlkylator/Crosslinker;?DNA/RNASynthesis |
體內(nèi)研究: |
Procarbazine (Intraperitoneal injection; 50 and 150 mg/kg; once daily; 5 d) induces micronuclei in hematopoietic cells, but not increases the lacZ mutant frequency (MF) in bone marrow |
參考文獻(xiàn): |
1. J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49(1):127-33. 2. T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444(2):269-81. |
溶解性: |
H2O : 100 mg/mL (387.96 mM; Need ultrasonic) DMSO : 16.67 mg/mL (64.67 mM; Need ultrasonic) |
保存條件: |
2-8℃ |
配置溶液濃度參考: |
|
1mg |
5mg |
10mg |
1 mM |
3.88 ml |
19.398 ml |
38.796 ml |
5 mM |
0.776 ml |
3.88 ml |
7.759 ml |
10 mM |
0.388 ml |
1.94 ml |
3.88 ml |
50 mM |
0.078 ml |
0.388 ml |
0.776 ml |
|
注意: |
部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。 |