| 貨號(hào) | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購(gòu)買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80668-2mg |
99.1% | ￥300.00 | 5 | - | - | - |
|
S80668-5mg |
99.1% | ￥420.00 | 5 | - | - | - |
|
S80668-10mg |
99.1% | ￥640.00 | 5 | - | - | - |
|
S80668-25mg |
99.1% | ￥1320.00 | 6 | - | - | - |
|
S80668-50mg |
≥99% | ￥2320.00 | 貨期：2-3天 | - | - | - |
|
S80668-100mg |
≥99% | ￥3920.00 | 貨期：2-3天 | - | - | - |
|
S80668-200mg |
≥99% | ￥5360.00 | 貨期：2-3天 | - | - | - |
|
Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues
| 產(chǎn)品描述： | Optovin is a reversible photoactivated TRPA1 ligand that enables light-mediated neuronal excitation. Optovin activates TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點(diǎn)： | TRP Channel;TRP/TRPVChannel | ||||||||||||||||||||
| 體外研究： | Optovin (1-10 μM) increases Zebrafish embryos motor activity greater than 40 standard deviations above the control mean at the photic stimuli, with an EC50 of 2 μM. Optovin (100 μM; 120 s) strongly activates 33% (35/105) of dorsal root ganglia (DRG) neurons. Optovin (10 μM; 1 min) activates HEK293T cells transfected with hTrpA1 | ||||||||||||||||||||
| 體內(nèi)研究： | Optovin (1-10 μM) causes light-dependent motor excitation in vivo. Optovin (15 mM (20 μL); on the ear) elicits nociceptive behaviors in adult mice. Optovin (10 μM; 96 h) do not affect the appearance, touch response, heart rate, fin movements, morphology or percentage survival of larvae and adult zebrafish | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. Kokel D, et al. Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol. 2013 Apr;9(4):257-63. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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