| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80619-2mg |
99.3% | ￥200.00 | 5 | - | - | - |
|
S80619-5mg |
99.3% | ￥270.00 | 6 | - | - | - |
|
S80619-10mg |
99.3% | ￥470.00 | 7 | - | - | - |
|
S80619-25mg |
99.3% | ￥970.00 | 5 | - | - | - |
|
S80619-50mg |
≥99% | ￥1850.00 | 貨期：2-3天 | - | - | - |
|
S80619-100mg |
≥99% | ￥2700.00 | 貨期：2-3天 | - | - | - |
|
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth
| 產(chǎn)品描述： | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth | ||||||||||||||||||||
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| 靶點： | IC50: 26 nM (Notch);Gamma-secretase | ||||||||||||||||||||
| 體內(nèi)研究： | IMR-1 (i.p.; 15mg/kg; for 28 days) inhibits Notch-dependent tumor growth in patient-derived xenograft models. Animal Model: Nude mouses with adenocarcinoma xenograft Dosage: 15mg/kg Administration: I.p.; for 28 days Result: Blocks tumor establishment. | ||||||||||||||||||||
| 參考文獻： | 1. Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603. | ||||||||||||||||||||
| 溶解性： | soluble in DMSO | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
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危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京