貨號	規(guī)格	價格	上海	北京	武漢	南京
S80587-5mg	98.5%	￥200.00 S80587-5mg ￥200.00 現(xiàn)貨	12 >10	-	-	-
S80587-10mg	98.5%	￥320.00 S80587-10mg ￥320.00 現(xiàn)貨	2 2	-	-	-
S80587-25mg	98.5%	￥630.00 S80587-25mg ￥630.00 現(xiàn)貨	6 6	-	-	-
S80587-50mg	98.5%	￥800.00 S80587-50mg ￥800.00 現(xiàn)貨	1 1	-	-	-
S80587-100mg	≥98%	￥1317.50 S80587-100mg ￥1317.50 2-3天	0 貨期：2-3天	-	-	-
S80587-200mg	≥98%	￥2550.00 S80587-200mg ￥2550.00 2-3天	0 貨期：2-3天	-	-	-
S80587-250mg	≥98%	￥2900.00 S80587-250mg ￥2900.00 2-3天	0 貨期：2-3天	-	-	-

大包裝詢價收藏產(chǎn)品

加入購物車

產(chǎn)品介紹

XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation

產(chǎn)品描述：

靶點：

TNKS2:2 nM (IC50);TNKS1:5 nM (IC50);ARTD2:479 nM (IC50)；ARTD1：5500 nM (IC50);PARP;Wnt/beta-catenin

體內(nèi)研究：

XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo

參考文獻(xiàn)：

1. Mohit Narwal, et al. Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24;56(20):7880-9. 2. Nuha Almasoud, et al. Tankyrase inhibitor XAV-939 enhances osteoblastogenesis and mineralization of human skeletal (mesenchymal) stem cells. Sci Rep. 2020 Oct 7;10(1):16746. 3. Senxin Cai, et al. Mechanical stress reduces secreted frizzled-related protein expression and promotes temporomandibular joint osteoarthritis via Wnt/β-catenin signaling. Bone. 2022 Aug;161:116445.

溶解性：

DMSO : 15.62 mg/mL (50.01 mM; ultrasonic and warming and heat to 60°C) H2O : < 0.1 mg/mL (insoluble)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.202 ml	16.01 ml	32.019 ml
5 mM	0.64 ml	3.202 ml	6.404 ml
10 mM	0.32 ml	1.601 ml	3.202 ml
50 mM	0.064 ml	0.32 ml	0.64 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(2篇)

2. [IF=4.4] Yumiao Mai et al."TARDBP drives T-cell acute lymphoblastic leukemia progression by binding MDM2 mRNA, involving β-catenin pathway."FASEB JOURNAL.2024 Oct;38(20):e70110 1. [IF=2.751] Shixiong Lei et al."CRP?1 promotes the malignant behavior of hepatocellular carcinoma cells via activating epithelial?mesenchymal transition and Wnt/β?catenin signaling."Experimental and Therapeutic Medicine.2023 Jul;26(1):1-10

質(zhì)檢證書(COA)

輸入產(chǎn)品批號：

如何獲取質(zhì)檢證書(COA)?

請輸入貨號和一個與之匹配的批號。
例如:
批號：JS298415 貨號：S20001-25g
在貨品標(biāo)簽上如何找到貨號和批號?

摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計算重置

国产精品+调教,sao货水真多把你cao烂动态,小说女频修仙,被合租刑警的粗汉肉h高np,波多官能人小说电影番号,我的姐夫是太子小说全集完整版txt,男生和女生一起差差差很痛的app下载,午夜福利日本精品,亲嘴一边揉一边往下摸视频