| 貨號(hào) | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購(gòu)買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80510-1mg |
98.3% | ￥200.00 | 6 | - | - | - |
|
S80510-2mg |
98.3% | ￥360.00 | 7 | - | - | - |
|
S80510-5mg |
98.3% | ￥520.00 | 6 | - | - | - |
|
S80510-10mg |
98.3% | ￥600.00 | 8 | - | - | - |
|
S80510-25mg |
98.3% | ￥750.00 | 4 | - | - | - |
|
S80510-50mg |
≥98% | ￥950.00 | 貨期：2-3天 | - | - | - |
|
S80510-100mg |
≥98% | ￥1570.00 | 貨期：2-3天 | - | - | - |
|
PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC
| 產(chǎn)品描述： | PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點(diǎn)： | EGFR:0.7 nM (IC50);Apoptosis;EGFR;FGFR;IGF-1R;PDGFR;PKC;Autophagy | ||||||||||||||||||||
| 體內(nèi)研究： | PD168393 (intraperitoneal injection; 58 mg/kg; once daily; days 10-14, 17-21, and 24-28) is effective in vivo, and produces tumor growth inhibition of 115% after 15 days’ treatment in human epidermoid carcinoma xenografts in mice | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. D W Fry, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12022-7. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 30 mg/mL (81.25 mM) | ||||||||||||||||||||
| 保存條件： | RT | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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