貨號	規(guī)格	價格	上海	北京	武漢	南京
S80479-1mg	≥98%	￥331.00 S80479-1mg ￥331.00 現(xiàn)貨	9 9	-	-	-
S80479-5mg	≥98%	￥835.00 S80479-5mg ￥835.00 現(xiàn)貨	10 10	-	-	-
S80479-10mg	≥98%	￥1420.00 S80479-10mg ￥1420.00 現(xiàn)貨	8 8	-	-	-
S80479-25mg	≥98%	￥3022.00 S80479-25mg ￥3022.00 現(xiàn)貨	8 8	-	-	-
S80479-50mg	≥98%	￥5146.00 S80479-50mg ￥5146.00 現(xiàn)貨	6 6	-	-	-
S80479-100mg	≥98%	￥8755.00 S80479-100mg ￥8755.00 現(xiàn)貨	5 5	-	-	-

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產(chǎn)品介紹

NCT-501 is a potent and selective theophylline-based inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), inhibits hALDH1A1 with IC50 of 40 nM, typically shows better selectivity over other ALDH isozymes and other dehydrogenases (hALDH1B1, hALDH3A1, and hALDH2, IC50 >57 μM).

產(chǎn)品描述：

靶點：

IC50: 40 nM (hALDH1A1);Dehydrogenase

體內(nèi)研究：

NCT-501 (100 μg/animal; i.t.; every alternate day for 20 days) shows a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts. Animal Model: 5-6 weeks old male Hsd: Athymic Nude-Foxn1nu (immuno-deficient-mice bearing Cal-27 CisR cells) Dosage: 100μg/animal Administration: Intra-tumorally (i.t); every alternate day for 20 days Result: Showed a 78% inhibition in tumor growth in Cal-27 CisR derived xenografts.

參考文獻(xiàn)：

1. Kulsum S et al. Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by Aldehydedehydrogenase 1 A1 inhibition. Mol Carcinog. 2016 Jul 6. 2. Yang SM, et al. Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1(ALDH1A1). J Med Chem. 2015 Aug 13;58(15):5967-5978.

溶解性：

Soluble in DMSO

保存條件：

-20°C

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.401 ml	12.004 ml	24.009 ml
5 mM	0.48 ml	2.401 ml	4.802 ml
10 mM	0.24 ml	1.2 ml	2.401 ml
50 mM	0.048 ml	0.24 ml	0.48 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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