貨號	規(guī)格	價格	上海	北京	武漢	南京
S80476-2mg	99.6%	￥544.00 S80476-2mg ￥544.00 現(xiàn)貨	1 1	-	-	-
S80476-5mg	≥98%	￥782.00 S80476-5mg ￥782.00 2-3天	0 貨期：2-3天	-	-	-
S80476-10mg	99.6%	￥1224.00 S80476-10mg ￥1224.00 現(xiàn)貨	3 3	-	-	-
S80476-25mg	99.6%	￥2244.00 S80476-25mg ￥2244.00 現(xiàn)貨	5 5	-	-	-
S80476-50mg	99.6%	￥3876.00 S80476-50mg ￥3876.00 現(xiàn)貨	2 2	-	-	-
S80476-100mg	≥98%	￥6052.00 S80476-100mg ￥6052.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

BAY-876 is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4[1]. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth

產(chǎn)品描述：

靶點：

GLUT1:2 nM (IC50);GLUT2:10.08 μM (IC50);GLUT3:1.67 μM (IC50);GLUT4;0.29 μM (IC50);transporter

體外研究：

BAY-876 (25-75 nM; 24 and 72 hours) has the growth-inhibitory effect and leads to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells. Cell Proliferation Assay Cell Line: SKOV-3 and OVCAR-3 cells Concentration: 25, 50, 75 nM Incubation Time: 24 and 72 hours Result: Led to a dose-dependent decrease in numbers of SKOV-3 and OVCAR-3 cells.

體內(nèi)研究：

BAY-876 (oral administration; 1.5-4.5 mg/kg/day for 28 days) causes a clear dose-dependent inhibition of tumorigenicity in mice. Animal Model: Female NOD-scid IL2rgnull (NSG) mice carrying SKOV-3 subcutaneous (s.c.) xenografts Dosage: 1.5, 3, 4.5 mg/kg Administration: Oral administration; daily; for 28 days Result: Caused a clear dose-dependent inhibition of tumorigenicity.

參考文獻：

1. Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23. 2. Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel). 2018 Dec 31;11(1).

溶解性：

Soluble in DMSO、Methanol

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.014 ml	10.072 ml	20.144 ml
5 mM	0.403 ml	2.014 ml	4.029 ml
10 mM	0.201 ml	1.007 ml	2.014 ml
50 mM	0.04 ml	0.201 ml	0.403 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻(1篇)

1. [IF=11.467] Chao Li et al."Core-shell nanosystems designed for effective oral delivery of polypeptide drugs."JOURNAL OF CONTROLLED RELEASE.2022 Dec;352:540

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