貨號	規(guī)格	價格	上海	北京	武漢	南京	購買數(shù)量
S80426-5mg	≥99%	￥1200.00 S80426-5mg ￥1200.00 2-3天	0 貨期：2-3天	-	-	-
S80426-25mg	≥99%	￥3200.00 S80426-25mg ￥3200.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

產(chǎn)品描述：

Allopurinol riboside, a metabolite of allopurinol, shows potent activities against parasites.

靶點：

Leishmania;EndogenousMetabolite;Parasite;DrugMetabolite

體內(nèi)研究：

Allopurinol riboside peaks in plasma 1.6 hours after administration, has an elimination half-life of 3 hours, and steady-state concentrations in the therapeutic range. After oral administration, unexpectedly low levels of allopurinol riboside in plasma are attributable to incomplete absorption and rapid renal clearance. Probenecid reduces the renal clearance of allopurinol riboside, extends the half-life of allopurinol riboside in plasma, and triples the levels of allopurinol riboside in plasma

參考文獻：

1. Nishida Y, et al. Inhibition of purine nucleoside phosphorylase activity and of T-cell function with allopurinol-riboside. Agents Actions. 1979 Dec;9(5-6):549-52. 2. Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114. 3. Shapiro TA, et al. Pharmacokinetics and metabolism of allopurinol riboside. Clin Pharmacol Ther. 1991 May;49(5):506-14. 4. Were JB, et al. Effects of probenecid on the pharmacokinetics of allopurinol riboside. Antimicrob Agents Chemother. 1993 May;37(5):1193-6.

溶解性：

Soluble in DMSO

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	3.728 ml	18.641 ml	37.282 ml
5 mM	0.746 ml	3.728 ml	7.456 ml
10 mM	0.373 ml	1.864 ml	3.728 ml
50 mM	0.075 ml	0.373 ml	0.746 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

質(zhì)檢證書(COA)

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摩爾濃度計算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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ALLOPURINOL RIBOSIDE