| 貨號(hào) | 規(guī)格 | 價(jià)格 | 上海 | 北京 | 武漢 | 南京 | 購(gòu)買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80345-5mg |
98.1% | ￥130.00 | 8 | - | - | - |
|
S80345-10mg |
98.1% | ￥200.00 | 9 | - | - | - |
|
S80345-25mg |
≥98% | ￥400.00 | 貨期：2-3天 | - | - | - |
|
S80345-50mg |
98.1% | ￥700.00 | 7 | - | - | - |
|
S80345-100mg |
≥98% | ￥940.00 | 貨期：2-3天 | - | - | - |
|
Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
| 產(chǎn)品描述： | Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3β, with IC50s of 0.4 μM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 μM, 7.5 μM, 0.85 μM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro. | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點(diǎn)： | Cdk1/cyclin B：0.4 μM (IC50)；cdk2/cyclin A：0.68 μM (IC50)；CDK5/p35：0.85 μM (IC50)；CDK2/cyclinE：7.5 μM (IC50)；GSK-3β：0.023 μM (IC50)；erk1：20 μM (IC50)；erk2：9 μM (IC50)；c-raf：38 μM (IC50);GSK-3;CDK | ||||||||||||||||||||
| 參考文獻(xiàn)： | 1. Zaharevitz DW, et al. Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res. 1999 Jun 1;59(11):2566-9. 2. Lyssiotis CA, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. 3. F Yu, et al. Kruppel-like factor 4 (KLF4) is required for maintenance of breast cancer stem cells and for cell migration and invasion. Oncogene. 2011 May 5;30(18):2161-72. | ||||||||||||||||||||
| 溶解性： | DMSO : ≥ 35 mg/mL (106.97 mM) | ||||||||||||||||||||
| 保存條件： | 2-8℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
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