貨號	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80208-1mg	98.1%	￥240.00 S80208-1mg ￥240.00 現(xiàn)貨	10 10	-	-	-
S80208-2mg	98.1%	￥420.00 S80208-2mg ￥420.00 現(xiàn)貨	10 10	-	-	-
S80208-5mg	98.1%	￥580.00 S80208-5mg ￥580.00 現(xiàn)貨	7 7	-	-	-
S80208-10mg	98.1%	￥1100.00 S80208-10mg ￥1100.00 現(xiàn)貨	8 8	-	-	-
S80208-25mg	98.1%	￥2250.00 S80208-25mg ￥2250.00 現(xiàn)貨	6 6	-	-	-
S80208-50mg	≥98%	￥3700.00 S80208-50mg ￥3700.00 2-3天	0 貨期：2-3天	-	-	-
S80208-100mg	≥98%	￥5300.00 S80208-100mg ￥5300.00 2-3天	0 貨期：2-3天	-	-	-

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產(chǎn)品介紹

XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively

產(chǎn)品描述：

XMD8-87 is a potent TNK2 inhibitor with IC50 values of 38 and 113 nM for the D163E and R806Q mutations, respectively

靶點(diǎn)：

IC50: 38 nM (TNK2, D163E mutation), 113 nM (TNK2, R806Q mutation);Tyrosinase;PPAR

體外研究：

XMD8-87 potently inhibits the growth of the TNK2 mutant expressing cell lines while having little or no effect on the control cells out to the highest tested concentrations (1,000 nM). XMD8-87 has IC50s of 38 nM and 113 nM for the D163E and R806Q mutations. The effects of XMD8-87 on TNK2 cell lines are largely due to on-target effects on TNK2. Auto-phosphorylation of overexpressed TNK2 mutants could be blocked with TNK2 inhibitor XMD8-87

參考文獻(xiàn)：

1. Maxson JE, et al. Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.245 ml	11.223 ml	22.446 ml
5 mM	0.449 ml	2.245 ml	4.489 ml
10 mM	0.224 ml	1.122 ml	2.245 ml
50 mM	0.045 ml	0.224 ml	0.449 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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