貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80170-1mg	98.7%	￥232.00 S80170-1mg ￥232.00 現(xiàn)貨	4 4	-	-	-
S80170-2mg	98.7%	￥416.00 S80170-2mg ￥416.00 現(xiàn)貨	8 8	-	-	-
S80170-5mg	98.7%	￥640.00 S80170-5mg ￥640.00 現(xiàn)貨	8 8	-	-	-
S80170-10mg	98.7%	￥960.00 S80170-10mg ￥960.00 現(xiàn)貨	8 8	-	-	-
S80170-25mg	98.7%	￥1920.00 S80170-25mg ￥1920.00 現(xiàn)貨	6 6	-	-	-
S80170-50mg	98.7%	￥3360.00 S80170-50mg ￥3360.00 現(xiàn)貨	5 5	-	-	-
S80170-100mg	98.7%	￥4480.00 S80170-100mg ￥4480.00 現(xiàn)貨	2 2	-	-	-

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產(chǎn)品介紹

N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.

產(chǎn)品描述：

N6022(IC50 of 8 nM) is an effective, reversible, and selective S-Nitrosoglutathione reductase(GSNOR) inhibitor.

靶點(diǎn)：

GSNOR

體外研究：

N6022 binds to rat plasma proteins in a concentration-dependent manner. At lower drug concentrations (20 μM), N6022 show more effect on ATP than on GSH. N6022 (IC50 of 8 nM and a Ki of 2.5 nM) binds in the GSNO substrate binding pocket like a competitive inhibitor. N6022 is uncompetitive with cofactors NAD+ and NADH.

體內(nèi)研究：

N6022 treats rats in 50 mg/kg leading to a slight increase in the incidence of granulomas. In serum, N6022 remained in solution is up to 5 mg/mL.

細(xì)胞實(shí)驗(yàn)：

N6022 is dissolved in 5% DMSO. N6022 is tested using a rat hepatoma (H4IIE) cell line whereby cells are seeded into 96-well plates and cultured in medium containing 20% bovine serum. Following an equilibration period of 48 h, the cells are treated with N6022 (5% DMSO vehicle) at concentrations of 0, 1, 5, 10, 20, 50, 100, and 300 μM for 24 h at 37°C in 5% CO2. Camptothecin and rotenone are included as positive controls. The cell supernatant or the cells themselves are harvested for biochemical analysis.

參考文獻(xiàn)：

1. Green LS, et al. Mechanism of inhibition for N6022, a first-in-class drug targeting S-nitrosoglutathione reductase. Biochemistry. 2012, 51(10), 2157-2168 2. Sun X, et al. Discovery of s-nitrosoglutathione reductase inhibitors: potential agents for the treatment of asthma and other inflammatory diseases. ACS Med Chem Lett. 2011, 2(5), 402-406.

溶解性：

soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.413 ml	12.064 ml	24.128 ml
5 mM	0.483 ml	2.413 ml	4.826 ml
10 mM	0.241 ml	1.206 ml	2.413 ml
50 mM	0.048 ml	0.241 ml	0.483 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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N6022

1-[4-(Aminocarbonyl)-2-methylphenyl]-5-[4-(1H-imidazol-1-yl)phenyl]-1H-pyrrole-2-propanoic acid