貨號	規(guī)格	價格	上海	北京	武漢	南京
S80088-5mg	≥98%	￥593.00 S80088-5mg ￥593.00 現(xiàn)貨	10 10	-	-	-
S80088-10mg	≥98%	￥904.00 S80088-10mg ￥904.00 現(xiàn)貨	10 10	-	-	-
S80088-25mg	≥98%	￥1852.00 S80088-25mg ￥1852.00 現(xiàn)貨	10 10	-	-	-
S80088-50mg	≥98%	￥2965.00 S80088-50mg ￥2965.00 現(xiàn)貨	10 10	-	-	-
S80088-100mg	≥98%	￥4633.00 S80088-100mg ￥4633.00 現(xiàn)貨	6 6	-	-	-
S80088-250mg	≥98%	￥9268.00 S80088-250mg ￥9268.00 現(xiàn)貨	1 1	-	-	-

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產(chǎn)品介紹

CCT 137690 is a potent and orally available aurora kinase inhibitor with IC50s of 15, 25, and 19 nM for aurora A, B and C, respectively.

產(chǎn)品描述：

CCT 137690 is a potent and orally available aurora kinase inhibitor with IC50s of 15, 25, and 19 nM for aurora A, B and C, respectively.

靶點(diǎn)：

Aurora A:15 nM (IC50);Aurora B:25 nM (IC50);Aurora C:19 nM (IC50);Apoptosis;AuroraKinase;Autophagy

體內(nèi)研究：

CCT 137690 slows the growth of the SW620 xenografts with no observed toxicity. CCT 137690 significantly inhibits tumour growth in a transgenic mouse model of neuroblastoma (TH-MYCN) that overexpresses MYCN protein and is predisposed to spontaneous neuroblastoma formation

參考文獻(xiàn)：

1. Bavetsias V, et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010 Jul 22;53(14):5213-28. 2. Faisal A, et al. The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo. Mol Cancer Ther. 2011 Nov;10(11):2115-23.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.813 ml	9.067 ml	18.133 ml
5 mM	0.363 ml	1.813 ml	3.627 ml
10 mM	0.181 ml	0.907 ml	1.813 ml
50 mM	0.036 ml	0.181 ml	0.363 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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