貨號	規(guī)格	價格	上海	北京	武漢	南京
S80080-100mg	99.5%	￥340.00 S80080-100mg ￥340.00 現(xiàn)貨	7 7	-	-	-
S80080-500mg	≥98%	￥850.00 S80080-500mg ￥850.00 2-3天	0 貨期：2-3天	-	-	-
S80080-1g	≥98%	￥1500.00 S80080-1g ￥1500.00 2-3天	0 貨期：2-3天	-	-	-

產(chǎn)品介紹

Mizolastine is an orally active, high affinity and specific peripheral histamine H1 receptor antagonist (second generation antihistamine). Mizolastine effectively inhibits mRNA expression of VEGF165, VEGF120, TNF-α and KC. Mizolastine can be used in studies of allergic rhinitis and chronic idiopathic urticarial

產(chǎn)品描述：

靶點：

Histamine Receptor;HistamineReceptor

體內(nèi)研究：

Mizolastine (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model

參考文獻：

1. Xia Q, et al. The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine. Clin Exp Dermatol. 2005 Mar 2. Ren X, et al. The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model. Mol Med Rep. 2017 Oct;16(4):4045-4053. 3. Prakash A, et al. Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria. BioDrugs. 1998 Jul;10(1):41-63.

溶解性：

DMSO : 25 mg/mL (57.80 mM; Need ultrasonic) H2O : 1 mg/mL (2.31 mM; ultrasonic and warming and heat to 80°C)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.312 ml	11.561 ml	23.122 ml
5 mM	0.462 ml	2.312 ml	4.624 ml
10 mM	0.231 ml	1.156 ml	2.312 ml
50 mM	0.046 ml	0.231 ml	0.462 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻

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