貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80044-1mg	≥96%	￥142.00 S80044-1mg ￥142.00 現(xiàn)貨	10 10	-	-	-
S80044-5mg	≥96%	￥499.00 S80044-5mg ￥499.00 現(xiàn)貨	10 10	-	-	-
S80044-10mg	≥96%	￥799.00 S80044-10mg ￥799.00 現(xiàn)貨	9 9	-	-	-
S80044-25mg	≥96%	￥1599.00 S80044-25mg ￥1599.00 現(xiàn)貨	4 4	-	-	-
S80044-50mg	≥96%	￥2727.00 S80044-50mg ￥2727.00 現(xiàn)貨	3 3	-	-	-
S80044-100mg	≥96%	￥4637.00 S80044-100mg ￥4637.00 現(xiàn)貨	2 2	-	-	-

大包裝詢價(jià) 收藏產(chǎn)品

加入購(gòu)物車

產(chǎn)品介紹

TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.

產(chǎn)品描述：

TAK-733 is a potent and selective MEK allosteric site inhibitor with an IC50 of 3.2 nM.

靶點(diǎn)：

MEK:3.2 nM (IC50);MEK

體內(nèi)研究：

The pharmacokinetics of TAK-733 is evaluated in nude mouse, rat, dog and monkey. Low clearance and high oral bioavailability are observed in all species. TAK-733 demonstrates broad antitumor activity in mouse xenograft models of human cancer including models of melanoma, colorectal, NSCLC, pancreatic and breast cancer. Daily oral administration of 1, 3, 10, and 30 mg/kg of TAK-733 for 14 days (Days 10 to 23) results in tumor growth delay in the A375 cell-implanted mice (5/group). TAK-733 (35, 70, 100, and 160 mg/kg) also significantly inhibits tumor growth on an intermittent dosing schedule of 3 days per week for 2 weeks (Days 10, 13, 15, 17, 20, and 22). Three partial regressions (PR), a 60% response rate, are observed in mice administered with 30 mg/kg of TAK-733 daily and in mice administered with 160 mg/kg of TAK-733 intermittently. Responses, CR (complete regression) and partial regressions (PR) are also observed in mice administered with 70, 100, and 160 mg/kg of TAK-733 intermittently. The tumor regression rate is more pronounced with the intermittent administration regimen; the greatest reduction in tumor volume is observed at 160 mg/kg (57.29%), versus a maximum reduction of 46.97% at 30 mg/kg once daily. By the last day of administration, tumor growth is significantly (p<0.05 for %T/C, Student's t-test) inhibited in mice administered 3, 10, and 30 mg/kg once daily or 35, 70, 100, and 160 mg/kg intermittently

參考文獻(xiàn)：

1. Dong Q, et al. Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1315-9. 2. Micel LN, et al. Antitumor activity of the MEK inhibitor TAK-733 against melanoma cell lines and patient-derived tumor explants. Mol Cancer Ther. 2015 Feb;14(2):317-25.

溶解性：

Soluble in DMSO

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	1.983 ml	9.916 ml	19.832 ml
5 mM	0.397 ml	1.983 ml	3.966 ml
10 mM	0.198 ml	0.992 ml	1.983 ml
50 mM	0.04 ml	0.198 ml	0.397 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

質(zhì)檢證書(shū)(COA)

輸入產(chǎn)品批號(hào)：

如何獲取質(zhì)檢證書(shū)(COA)?

請(qǐng)輸入貨號(hào)和一個(gè)與之匹配的批號(hào)。
例如:
批號(hào)：JS298415 貨號(hào)：S20001-25g
在貨品標(biāo)簽上如何找到貨號(hào)和批號(hào)?

摩爾濃度計(jì)算器

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

質(zhì)量

濃度

體積

分子摩爾量

計(jì)算重置

国产精品+调教,sao货水真多把你cao烂动态,小说女频修仙,被合租刑警的粗汉肉h高np,波多官能人小说电影番号,我的姐夫是太子小说全集完整版txt,男生和女生一起差差差很痛的app下载,午夜福利日本精品,亲嘴一边揉一边往下摸视频