| 貨號 | 規(guī)格 | 價格 | 上海 | 北京 | 武漢 | 南京 | 購買數(shù)量 |
|---|---|---|---|---|---|---|---|
S80039-1mg |
98.5% | ￥290.00 | 4 | - | - | - |
|
S80039-2mg |
98.5% | ￥500.00 | 5 | - | - | - |
|
S80039-5mg |
98.5% | ￥930.00 | 5 | - | - | - |
|
S80039-10mg |
98.5% | ￥1490.00 | 5 | - | - | - |
|
S80039-25mg |
98.5% | ￥2750.00 | 6 | - | - | - |
|
S80039-50mg |
98.5% | ￥4100.00 | 5 | - | - | - |
|
S80039-100mg |
98.5% | ￥5800.00 | 5 | - | - | - |
|
Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity
| 產(chǎn)品描述： | Copanlisib (BAY 80-6946) is a potent, selective and ATP-competitive pan-class I PI3K inhibitor, with IC50s of 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. Copanlisib has more than 2,000-fold selectivity against other lipid and protein kinases, except for mTOR. Copanlisib has superior antitumor activity | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 靶點： | PI3Kα：0.5 nM (IC50)；PI3Kβ：3.7 nM (IC50)；PI3Kδ：0.7 nM (IC50)；PI3Kγ：6.4 nM (IC50)；mTOR：45 nM (IC50);Apoptosis;PI3K | ||||||||||||||||||||
| 體內(nèi)研究： | Copanlisib (BAY 80-6946; 0.5-6 mg/kg; intravenous injection; every second day, every third day; for 60 days; athymic nude rats) treatment displays robust antitumor activity in the rat KPL4 tumor xenograft model | ||||||||||||||||||||
| 參考文獻： | 1. Liu N, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol Cancer Ther. 2013 Nov;12(11):2319-30. | ||||||||||||||||||||
| 溶解性： | 1M HCl : 100 mg/mL (208.11 mM; Need ultrasonic) | ||||||||||||||||||||
| 保存條件： | -20℃ | ||||||||||||||||||||
| 配置溶液濃度參考： |
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| 注意： | 部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。 |
上海工商
滬公網(wǎng)安備 31011702002021號
危險品化學品經(jīng)營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京