貨號(hào)	規(guī)格	價(jià)格	上海	北京	武漢	南京
S80017-1mg	99.7%	￥200.00 S80017-1mg ￥200.00 現(xiàn)貨	10 10	-	-	-
S80017-2mg	99.7%	￥344.00 S80017-2mg ￥344.00 現(xiàn)貨	4 4	-	-	-
S80017-5mg	99.7%	￥536.00 S80017-5mg ￥536.00 現(xiàn)貨	7 7	-	-	-
S80017-10mg	99.7%	￥880.00 S80017-10mg ￥880.00 現(xiàn)貨	6 6	-	-	-
S80017-25mg	99.7%	￥1520.00 S80017-25mg ￥1520.00 現(xiàn)貨	8 8	-	-	-
S80017-50mg	99.7%	￥2560.00 S80017-50mg ￥2560.00 現(xiàn)貨	8 8	-	-	-
S80017-100mg	99.7%	￥4800.00 S80017-100mg ￥4800.00 現(xiàn)貨	4 4	-	-	-

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產(chǎn)品介紹

Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.

產(chǎn)品描述：

Silmitasertib (CX-4945) is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'.

靶點(diǎn)：

CK2α:1 nM (IC50);CK2α':1 nM (IC50);CaseinKinase;Autophagy

體內(nèi)研究：

Silmitasertib (CX-4945) (25 or 75 mg/kg, p.o.) is well tolerated and demonstrated robust antitumor activity with concomitant reductions of the mechanism-based biomarker phospho-p21 (T145) in murine xenograft models

參考文獻(xiàn)：

1. Siddiqui-Jain A, et al. CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res. 2010 Dec 15;70(24):10288-98. 2. Buontempo F, et al. Synergistic cytotoxic effects of PS-341 and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Oncotarget. 2016 Jan 12;7(2):1323-40. 3. Chon HJ, et al. The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol. 2015 Mar 31;6:70.

溶解性：

DMSO : ≥ 35 mg/mL (100.07 mM) 0.1 M NaOH : 33.33 mg/mL (95.29 mM; ultrasonic and adjust pH to 9 with NaOH)

保存條件：

-20℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.859 ml	14.295 ml	28.59 ml
5 mM	0.572 ml	2.859 ml	5.718 ml
10 mM	0.286 ml	1.43 ml	2.859 ml
50 mM	0.057 ml	0.286 ml	0.572 ml

注意：

部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)

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批號(hào)：JS298415 貨號(hào)：S20001-25g
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CX-4945 (Silmitasertib)