貨號	規(guī)格	價格	上海	北京	武漢	南京
S80016-5mg	98.2%	￥272.00 S80016-5mg ￥272.00 現貨	9 9	-	-	-
S80016-10mg	98.2%	￥384.00 S80016-10mg ￥384.00 現貨	3 3	-	-	-
S80016-25mg	98.2%	￥800.00 S80016-25mg ￥800.00 現貨	4 4	-	-	-
S80016-50mg	98.2%	￥1520.00 S80016-50mg ￥1520.00 現貨	5 5	-	-	-
S80016-100mg	98.2%	￥2240.00 S80016-100mg ￥2240.00 現貨	5 5	-	-	-
S80016-200mg	≥98%	￥3600.00 S80016-200mg ￥3600.00 2-3天	0 貨期：2-3天	-	-	-
S80016-250mg	≥98%	￥4000.00 S80016-250mg ￥4000.00 2-3天	0 貨期：2-3天	-	-	-

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產品介紹

b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.

產品描述：

b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.

靶點：

UCHL5/Usp14;Apoptosis;DUB

體內研究：

b-AP15 (2.5 mg/kg) inhibits tumor growth in syngenic mice models with less frequent administration schedules. We administered b-AP15 to C57BL/6J mice with Lewis lung carcinomas (LLCs) using a 2-d-on, 2-d-off schedule and to BALB/c mice with orthotopic breast carcinoma (4T1) using a 1-d-on, 3-d-off schedule. b-AP15 significantly inhibited tumor growth in both models, with T/C=0.16 (P≤0.01) for the C57BL/6J mice and T/C=0.25 (P≤0.001) for the BALB/c mice. A reduction in the number of pulmonary metastases also is observed in the group of mice with 4T1 breast carcinomas treated with b-AP15

參考文獻：

1. D'Arcy P, et al. Inhibition of proteasome deubiquitinating activity as a new cancer therapy. Nat Med. 2011 Nov 6;17(12):1636-40. 2. Wang X, et al. The 19S Deubiquitinase Inhibitor b-AP15 is Enriched in Cells and Elicits Rapid Commitment to Cell Death. Mol Pharmacol. 2014 Jun;85(6):932-45. 3. Tian Z, et al. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 2014 Jan 30;123(5):706-16.

溶解性：

DMSO : 20 mg/mL (47.69 mM; Need ultrasonic)

保存條件：

2-8℃

配置溶液濃度參考：

	1mg	5mg	10mg
1 mM	2.384 ml	11.922 ml	23.844 ml
5 mM	0.477 ml	2.384 ml	4.769 ml
10 mM	0.238 ml	1.192 ml	2.384 ml
50 mM	0.048 ml	0.238 ml	0.477 ml

注意：

部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

參考文獻

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摩爾濃度計算器

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

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b-AP15 ( NSC 687852)

(3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one